Inhibition of Bovine Phenol Sulfotransferase (bSULT1A1) by CoA Thioesters
نویسندگان
چکیده
منابع مشابه
Inhibition of Bovine Phenol Sulfotransferase (bSULT1A1) by CoA Thioesters EVIDENCE FOR POSITIVE COOPERATIVITY AND INHIBITION BY INTERACTION WITH BOTH THE NUCLEOTIDE AND PHENOL BINDING
*This work was supported by a grant from the National Science Foundation. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. **To whom correspondence should be addressed: Department of Biochemistry, Alma College, 614 W. ...
متن کاملInhibition of bovine phenol sulfotransferase (bSULT1A1) by CoA thioesters. Evidence for positive cooperativity and inhibition by interaction with both the nucleotide and phenol binding sites.
Previous work with the bovine phenol sulfotransferase (bSULT1A1, EC ) demonstrated inhibition by CoA that was competitive with respect to the sulfuryl donor substrate, 3'-phosphoadenosine-5'-phosphosulfate (PAPS) (Leach, M., Cameron, E., Fite, N., Stassinopoulos, J., Palmreuter, N., and Beckmann, J. D. (1999) Biochem. Biophys. Res. Commun. 261, 815-819). Here we report that long chain acyl-CoAs...
متن کاملInhibition of Bovine Phenol Sulfotransferase (bSULT1A1) by CoA Thioesters EVIDENCE FOR POSITIVE COOPERATIVITY AND INHIBITION BY INTERACTION WITH BOTH THE NUCLEOTIDE AND PHENOL BINDING SITES* (Running title: Palmitoyl-CoA Inhibits Phenol Sulfotransferase )
*This work was supported by a grant from the National Science Foundation. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. **To whom correspondence should be addressed: Department of Biochemistry, Alma College, 614 W. ...
متن کاملUtilization of different fatty acyl-CoA thioesters by serine palmitoyltransferase from rat brain.
Serine palmitoyltransferase (EC 2.3.1.50) catalyzes the first unique reaction of sphingolipid biosynthesis. Activities were determined with different fatty acyl-CoA substrates to describe the range of long-chain bases that could be made by rat brain microsomes. The activities were greatest with palmitoyl-CoA and palmitelaidoyl-CoA, followed by fully saturated homologs differing from these by on...
متن کاملPurification and characterization of a canine liver phenol sulfotransferase.
Species differences in the metabolism of xenobiotics can present significant problems for safety and efficacy assessment during the development of new pharmaceutical agents. Identification of animal models for human metabolism and/or toxicology of any particular compound would significantly reduce the extent and cost of animal testing of novel candidate pharmaceuticals. Sulfation is an importan...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m206017200